Cell Shorts | Accelerating degenerative eye disease therapies

I always would say I wanted to be a doctor. And then everyone would say:
Oh yeah, you could treat us… And I’d say, no I don’t want to be a doctor that treats you, I want to be a doctor that actually makes new treatments. So…here I am. My name is Kapil Bharti and I’m an Earl Stadtman Investigator… here at the National Eye Institute at NIH. I run a group on studying and understanding how retinal degenerative diseases happen… and trying to develop new treatments for those diseases. One is called age-related macular degeneration, AMD. And it is a disease that affects millions of people worldwide. One of the main tissues we work on in the lab.. is a tissue called the retinal
pigment epithelium, the RPE. They actually help, the photoreceptors help the retina… they nourish the retina throughout its life. The RPE cells actually die off in
AMD patients… and as a result their photoreceptors are dying. And because of that, they start losing vision. This is one of the Allen Institute’s iPS cell lines. The Allen cell collection has been the most beautiful thing that I’ve recently seen. How do these cells actually polarize? So when I say polarized, they
acquire this 3-dimensional structure.. and they define their own locations. And nobody knows how that happens. No cell biologist has looked at it… because there was no way to look at it. And once I saw this announcement from the Allen Institute… I was like, this is it. This is a way to do it. We’re doing live imaging of every single organelle. And then we’re going to do 3d reconstruction at every time point so that we have a complete understanding of where the organelles are at a given time as the cells are polarizing. We’re at the same time perturbing those to see what would happen. If the cells were unhealthy, how would
these organelles behave? One of the main goals has been to develop a cell therapy for patients with AMD. And the idea was to deliver an a patch of RPE cells made from patients’ own IPS cells. So this has been work that we’re now trying to put together for a phase I clinical trial that we hope to submit to the FDA soon. Really my hope is that, combined together all the knowledge, all those new tools that we are creating will bring new treatments, even perhaps new cures for
these patients.

One comment

  1. السلام عليكم الأخ الكريم هل من الممكن مساعدتي الى التوصل إلى أحد الجامعات او المعاهد او الباحثين المختصين و المهتمين بخصوص الحياة عبر الزمن او المستقبل لأنني اعيش حياة لها علاقة مع المستقبل و ابحث عن مهتمين لدراستها و التي تشبه ما مدكور في هدا الفيديو https://youtu.be/XrurmZeiZl8Peace be upon you. Can you help me reach a university, institute or researcher who is interested and interested in life over time or future because I live a life that has to do with the future and I am interested in studying it, which is similar to what is documented in this video. youtu.be/XrurmZeiZl8

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