ADCIS Applications : Medical : Ophthalmology


Image processing and analysis has become an
important tool in the fields of biology and
medicine. This is especially true in Ophthalmology where
Image processing and analysis provides: accurate & reproducible measurements for
clinical studies, aids in efficient and rapid screening for a wide
range of eye diseases, in diagnosis, in documenting and monitoring changes over
time, as well as characterizing the efficacy of various
therapies. The scientists and engineers at ADCIS have
been active in the research and development of image processing and analysis in support of
ophthalmology for more than 30 years in areas such as Automatic detection of micro-
aneurisms in the field of diabetic retinopathy. They saw the evolution from black and white
angiographies to high definition color fundus
images and the development of OCT imaging. Over the past few years ADCIS was contracted
by Pfizer in 2008 to develop an automatic software product in the field of Age
Related Macula Degeneration. They performed custom engineering work for
Allergan, Alcon Laboratories, and Novartis. They have been acknowledged as an expert in
the field of ophthalmology in 2012 by The
French Government. Their years of experience and expertise have
resulted in the 5 ophthalmology applications
presented in this video: ARIES: A Confocal Rapid Image Evaluation
System for automatic processing and analysis of
corneal images. REVA: Retinal Volume Analyzer for the detection and analysis of retinal Pigment
Epithelial Detachment. ISOS: Imaging System for Ocular Surfaces for capture and quantitative characterization of
images needed for diagnosis and monitoring of therapies associated with
conjunctival hyperemia. VND: Vessel Network Detection for detection and segmentation of vessels and
Optic Nerve Detection. EyePrint Designer: for design of rigid contact and scleral lenses. ARIES is a stand-alone application that
provides fully automatic measurement of corneal microstructures from in vivo confocal
images. It requires only a few mouse clicks to
automatically identify the best nerve layer, and then to automatically detect the wing cells, the immune cells, and the nerve. At this point, the ophthalmologist can edit the
segmentation as needed. The results are displayed as a statistical
summary table and also as a grid of measurements of the
various shape properties of the different
microstructures. ARIES also provides for manual identification and counting especially for validation. Upon completion of the manual
measurements, the validation of the results is
presented as both a visual comparison of automatic and
manual identification of features and as a quantitative table of the
measurements. ARIES also provides true 3D characterization of the nerves giving enhanced understanding that cannot be
obtained from 2D analysis. ReV or Retinal Volume Analyzer is easy to use
software for detection and characterization of Pigment Epithelial Detachment (PED) using
OCT images. Image sets exported from instruments that use
software like the Heidelberg Eye Explore can be imported and the Ophthalmologist can
then view the images. A semi-automatic mode lets the user outline the
detachment in each section where it is visible, using a unique User Assisted tool that
automatically fits to the boundary of the
detachment. There are also tools for editing the identified
PED. An automatic mode is also available which
detects the detachment in the user defined
central section and then propagates that detection through all
the sections where the detachment is present. Whether by automatic or semi-automatic
modes, when the PED has been identified in all
of the sections it is characterized and the results are displayed quantitatively and
graphically in interactive 3D. ReVAnalyzer measures the PED volume, and
because it contains a patient database it
provides monitoring of PED evolution over time, and the information needed to evaluate
response to therapeutic treatments. ISOS is an automatic imaging & analysis
application. It uses a slit lamp system and a
digital SLR camera to generate high definition images of the ocular
surface, as well as software for the control of
image capture and storage that places the images into a
patient database. It also consists of software for manual grading
and for automatic grading by evaluating a variety of morphological parameters of vessels
associated with conjunctival hyperemia. It then provides an objective measurement in a few seconds of conjunctival hyperemia that is robust and highly correlated to manual
grading. The reviewer software provides quantitative and
graphical representations of both the manual
and automatic grading. ISOS provides a robust quantitative redness
grade that is based on a statistical analysis. It detects the vessel network and analyzes its
shape and density. And is used to track the evolution of the largest
vessel in terms of diameter and tortuosity. The ISOS product environment allows easy
global sharing of information and collaboration to ensure that the best data is collected, the
most accurate analysis is carried out, and the most effective diagnosis and treatment
are carried out. VND or Vessel Network Detection is the best vessel network detection algorithm
on the market. It’s based on a very advanced & sophisticated
approach. The algorithm works on color fundus and black
and white images including auto-fluorescence, red free, infrared
and fluorescein images. It’s an Aphelion extension and is used in the
Aphelion user interface. It adds two main functions to the interface: First is Vessel Extraction. Which makes it
possible to characterize the vessel structure and to compute measurements on the
branches such as the mean diameter along
that branch. It also provides Optic Nerve Detection. It fits the
best circle on the boundary of the optic nerve. The output of the vessel detection can be
converted into a binary image to be later used as a mask for pathology
detection, and further blood vessel analysis. ADCIS has developed lens design software for
EyePrint Prosthetics. This software provides the input for custom
made rigid contacts and scleral lenses for patients with damaged
corneas that are highly irregular and difficult to
fit. The EyePrintPRO Designer software intuitively
guides the user with a wizard concept, asking only for necessary, optics-oriented
information, to compute a smooth lens shape. To help users to quickly and easily design a
lens, the Graphical User Interface is made of a
set of windows that are context dependent. The software automatically computes the four
zone back surfaces of the lens. The user can manually tune each zone
clearance and diameter for both back and front
surfaces, add some extra clearance on painful areas
such as bumps and see the changes in real
time in the 3D viewer. The software handles various lens
prescriptions including: Decentered optics, multifocals, torics, prism in any direction, and High Optical Aberrations. When both surfaces have been computed, the software generates files that can be inputted
to a lathe to mill the custom fit lens. These five Applications for Ophthalmology from
the image processing and analysis experts at
ADCIS are part of a much larger collection of products
for medical, biological, and many other
applications. More information can be found at our website
http://www.adcis.net. We strongly encourage you to contact us. Our contact information is on the contact us
webpage. Thank you.

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